If ES250's were originally supposed to have a pre-mix of 33:1, then they would have been jetted accordingly.
Then as the TS250 came out, more stringent emission laws came from the localised government of East Germany, the TS250 had to be limited to a 50:1 (officially). The carburettors were changed accordingly. Don't forget though, that bikes in that region didn't cover the same amount of ground that they now do. And even at the time, In the UK it was common for TS250's that had been used constantly as despatch bikes to have seized owing to the constant 70mph motorway speeds back and forth about the country. The Germans didn't seem to have such business enterprises, if they did they were not inter-city.
I always found it odd how Eastern Germany decided for emission standards, where as Russia didn't, and still advocated 25:1, they still produce 2t motorcycles now.
Back to the point though, seeing as ES's are carburettored for 33:1 ratio, then the previous point about ratios being incorrect in the combustion chamber is besides the point.
Regardless, coming back to TS250 being set up for 50:1, and then running on 30:1 is also somewhat moot. The difference in the amount of fuel going into the engine is about 3% I believe, that is for the whole tank's worth, just 20cl. Practically nothing.